Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/193560543?client_source=feed&format=rss
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Tuesday, January 31, 2012
Fla. highway patrol defends reopening I-75 (AP)
GAINESVILLE, Fla. ? The Florida Highway Patrol says conditions were clear when they decided to reopen the interstate highway where 10 people were killed in two deadly pileups amid heavy smoke and fog.
Lt. Patrick Riordan said Monday in a news conference that visibility quickly deteriorated after they reopened the highway early Sunday morning. The crashes started shortly after.
About midnight, the highway patrol closed Interstate 75 near Gainesville because of low visibility but reopened it about 3:30 a.m. Pileups began about 15 minutes later, with survivors describing smoke and fog so thick they couldn't see.
Riordan says troopers did their "due diligence" before a sergeant and lieutenant decided to reopen the road. He says drivers have to be alert and be prepared to make good judgments.
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Monday, January 30, 2012
'Project Nim' wins Directors Guild doc award (omg!)
LOS ANGELES (AP) ? James Marsh won the documentary prize Saturday at the Directors Guild of America Awards for "Project Nim," his chronicle of the triumphs and trials of a chimpanzee that was raised like a human child.
It was the latest major Hollywood prize for Marsh, who earned the documentary Academy Award for 2008's "Man on Wire." Among those Marsh beat out for the guild award was Martin Scorsese, who had been up for the documentary honor for "George Harrison: Living in the Material World" and also was nominated for the evening's highest honor, for feature-film directing.
The film favorites were guild awards regular Scorsese for his Paris adventure "Hugo" and first-time nominee Michel Hazanavicius for his silent movie "The Artist."
Also in the running were Woody Allen for his romantic fantasy "Midnight in Paris"; David Fincher for his thriller "The Girl with the Dragon Tattoo"; and Alexander Payne for his family drama "The Descendants."
At the start of the ceremony, Guild President Taylor Hackford led the crowd in a toast to one of his predecessors, Gil Cates, the veteran producer of the Academy Awards broadcast who died last year.
Robert B. Weide won the comedy directing award for an episode of "Curb Your Enthusiasm."
Other early television winners at the guild ceremony were:
? Reality programming: Neil P. DeGroot, "The Biggest Loser."
? Musical variety: Glenn Weiss, "The 65th Annual Tony Awards."
? Daytime serials: William Ludel, "General Hospital."
? Children's programs: Amy Schatz, "A Child's Garden of Poetry."
? Commercials: Noam Murro.
The Directors Guild Awards are one of Hollywood's most accurate forecasts for who will win at the industry's top honors, the Oscars, which will be handed out Feb. 26. Only six times in the 63-year history of the guild awards has the winner failed to take home the Oscar for best director, and more often than not, the film winning the best director Oscar is voted best picture.
Fincher had been the favorite going into the Directors Guild ceremony last year for "The Social Network," but Tom Hooper came away the winner for "The King's Speech." Hooper went on to win the Oscar, too, and his film also earned best picture.
This time, Fincher's the odd man out at the Directors Guild show. The other four guild nominees made the best-director cut at Tuesday's Oscar nominations, but Fincher missed out. The fifth Oscar slot went to Terrence Malick for the family chronicle "The Tree of Life."
French filmmaker Hazanavicius, whose credits include the spy spoofs "OSS 117: Cairo, Nest of Spies" and "OSS 117: Lost in Rio," had been a virtual unknown in Hollywood until "The Artist," his black-and-white throwback to early cinema that has been a favorite at earlier film honors.
"The Artist" won the Golden Globe for best musical or comedy and is considered a best-picture front-runner for the Oscars.
But Scorsese won the Globe for directing over Hazanavicius.
Unlike Hazanavicius, the other nominees all have competed for Directors Guild honors before. Scorsese earned his ninth and 10th guild nominations this season for "Hugo" and his George Harrison documentary.
Scorsese is a past feature-film winner for 2006's "The Departed," as well as a TV drama winner a year ago for an episode of "Boardwalk Empire." The family film "Hugo" was a departure for Scorsese, known for dark crime tales, and the movie also was his first shot in 3-D.
Allen has been nominated five times and won for 1977's "Annie Hall." He had not been nominated since his 1989 "Crimes and Misdemeanors" but has been on a critical and commercial resurgence for "Midnight in Paris," his biggest hit in decades.
This was the third nomination for Fincher. Payne was nominated one time previously, for 2004's "Sideways."
___
Online:
http://www.dga.org
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Sunday, January 29, 2012
It's an entire theme park, driven by the Kinect
d'strict
By Matthew Hawkins
It's been a little over a year, and Microsoft's motion sensing add-on for the Xbox 360 has not lit the world of video games on fire. The only titles truly worth getting are "Dance Central" and "Dance Central 2." "Leela," the New Age-y program by Deepak Chopra is also noteworthy, but it's less a game and more of a tool for meditation. Nothing else on the horizon looks or sounds remotely interesting.
(Msnbc.com is a joint venture of Microsoft and NBCUniversal.)
Meanwhile, hackers and others have been having a field day with the Kinect. Not a week goes by in which someone hasn't figured a new wild and wacky way to repurpose it as a tool for interfacing with technology, creating art or just having fun. And now comes something that does all three.
It's called Live Park, the brainchild of d'strict, a South Korean-based new media venture. It's advertised as a theme park that "enables visitors to experience a virtual world previously only seen in movies like 'Minority Report' and 'Avatar.' " The somewhat difficult to decipher PR blast details attractions like "Ender Mirror," in which visitors create virtual counterparts and take pictures by laughing at something called a "smile engine."
Then there's "Live360," advertised as the world's biggest interactive stereoscopic theater. Via avatars, visitors can engage in a "realistic" video game with multiple endings. It, along with all the other attractions, are all powered by Kinect-driven displays that interact with visitors, all wearing RFID wristbands, and whose faces and voices are recognized by Microsoft's versatile peripheral.
Kotaku's mention of the place includes this trailer, which makes things a tad bit clear:
There are plans in place to expand Live Park into China and Singapore, plus other parts of Asia, along with North America, including Los Angeles and Las Vegas. The press release also notes: "Last year James Cameron announced plans for an 'Avatar' themed land at Disney's Animal Kingdom to begin construction in 2013. With 'Live Park', d'strict (will) have created a 4D avatar theme park that's here today!"
Related stories:
Matthew Hawkins is a NYC based game journalist who has also written for EGM, GameSetWatch, Gamasutra, Giant Robot, and numerous others. He also self-publishes his own game culture zine, is part of Attract Mode, and co-hosts of The Fangamer Podcast. You can keep tabs on him via?Twitter,?or his personal home-base,?FORT90.com.
Source: http://ingame.msnbc.msn.com/_news/2012/01/27/10253690-its-an-entire-theme-park-driven-by-the-kinect
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Boko Haram leader tape threatens Nigeria forces (Reuters)
KANO, Nigeria (Reuters) ? In an audio tape posted on the Internet, the purported leader of the violent Nigerian Islamist sect Boko Haram threatened to kill more security personnel and kidnap their families, and accused U.S. President Barack Obama of waging war on Islam.
In the 45-minute tape released on Thursday, a man's voice in the main northern Hausa language claimed to be Abubakar Shekau. He said President Goodluck Jonathan would fail to stop their insurgency.
Boko Haram's attacks have become more sophisticated and deadly in recent weeks in Africa's top oil producer. A series of gun and bomb attacks killed 186 people in Nigeria's second city of Kano last Friday.
"We were responsible for the attack in Kano, I gave the order and I will do it again and again. Allah gives us victory," the voice said.
If confirmed as authentic, the second tape in just under three weeks by Shekau would suggest he wants to use to media to establish his authority over the group, security sources said.
Shekau is said to have taken over control of Boko Haram, which wants sharia law more widely applied across Nigeria, after the sect's founder Mohammed Yusuf was killed in police custody in 2009 following an uprising in which 700 people were killed.
However, security experts say it is unclear whether Boko Haram really has a unified leadership.
Boko Haram, a movement loosely modeled on the Afghan Taliban whose name translates from the northern Hausa language as "Western education is sinful," has been behind almost daily killings in its home base in the largely Muslim northeast, and occasionally in the capital Abuja.
The Kano attack was their deadliest strike yet.
"We attacked the securities base because they were arresting our members and torturing our wives and children. They should know they have families too, we can abduct them. We have what it takes to do anything we want," the voice on the tape said.
But he denied responsibility for the civilian casualties, which police said made up 150 of the deaths.
"We never kill ordinary people, rather we protect them. It is the army that rushed to the press to say we are the ones killing civilians. We are not fighting civilians. We only kill soldiers, police and other security agencies," he said.
In August last year, the sect carried out a suicide car bombing of the United Nations headquarters in the capital Abuja that killed 24 people. On Christmas Day it masterminded coordinated explosions against Christians, including one at a church near Abuja that killed at least 37 people.
In a previous video tape on January 11, Shekau defended attacks against Christians.
President Jonathan told Reuters on Thursday that Boko Haram had made contact with other jihadist groups operating in the region, echoing views by security experts that AQIM has trained and supported some Boko Haram militants, though its interests remain local.
He challenged the group to identify themselves and state their demands as a basis for talks.
The tape hinted that Boko Haram was part of a global jihad against Western interests.
"In America, from former President George Bush to Obama, the Americans have always been fighting and destroying Islam," he said. "They have tagged us terrorists and they are paying for it. It is the same in Nigeria, and we will resist."
(Writing by Tim Cocks)
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Saturday, January 28, 2012
Euro rises against the dollar on US economic data (AP)
NEW YORK ? The euro is rising against the dollar after the U.S. released durable goods and jobs data.
The euro rose as high as $1.3184, its highest point in five weeks. The euro was worth $1.3084 late Wednesday.
Orders for durable goods rose last month, the Commerce Department said Thursday. Separately, the Labor Department said that unemployment rose last week to 377,000, but economists think the numbers point to a recovering job market.
The dollar was also falling against most other currencies. The dollar fell to 77.48 Japanese yen from 77.81 Japanese yen, to 0.9176 Swiss franc from 0.9231 Swiss franc and to 99.90 Canadian cents from 1.0053 Canadian dollar.
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Friday, January 27, 2012
?Welcome Back, Kotter? Star Robert Hegyes Dead At 60 (VIDEOS)
“Welcome Back, Kotter” Star Robert Hegyes Dead At 60 (VIDEOS)
“Welcome Back, Kotter” actor Robert Hegyes, who was known as the Jewish Puerto Rican student Juan Epstein on the popular 1970s show, has died at [...]
“Welcome Back, Kotter” Star Robert Hegyes Dead At 60 (VIDEOS) Stupid Celebrities Gossip Stupid Celebrities Gossip News
Source: http://feedproxy.google.com/~r/stupidcelebrities/~3/MfynYmmSNxU/
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Thursday, January 26, 2012
Roseanne Barr Calls Out Obama, Beyonce, "Drooling Mutant" Fans of Singer
Roseanne Barr is mourning the death of music legend Etta James in an odd way: by talking $hit about President Obama and Beyonce.
Basing a round of criticism on Obama asking Beyonce to cover the James classic "At Last" during a 2009 inauguration ball, Roseanne Tweeted yesterday: "I lost ALL respect for Obama when he dissed Etta James in favor of Beyonce," later adding:
"I have not listened to anything Beyonce or Jay z has said or recorded since they did that to Etta. Their arrogance was disgusting."
Roseanne, who actually just had a pilot picked up by NBC, then focused her rage on those who dare to support the new mother of Blue Ivy, writing: "Beyonce’s fans are really ignorant-she should not be proud of entertaining drooling mutants!"
Soon after Beyonce serenaded the Obamas with "At Last," James herself also called her and the President out - but both she and Roseanne appear to be missing a crucial point: James did not originally record the song, either. Her version was a cover of a cover.
[Photos: WENN.com]
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Netflix sees DVD business withering, gives up on video games ...
Netflix has given up all hope that there's a future in DVDs.
Just last summer, the subscription video company was touting the potential of its DVD business as it established a separate unit to focus on it. "In Q4, we'll also return to marketing our DVD-by-mail service, something we haven't done for many quarters," Chief Executive Reed Hastings and Chief Financial Officer David Wells said in a July letter to shareholders. "Our goal is to keep DVD as healthy as possible for as many years as possible."
But since the Qwikster debacle, when Netflix announced a separately branded business for DVD rentals and then abandoned it in the face of public outcry, the company appears to have given up on that goal.
On an earnings conference call with analysts Wednesday, Hastings said Netflix now has no plans to spend any marketing dollars on its DVD-by-mail service, which lost 2.76 million subscribers during the last three months of 2011.
"We expect DVD subscribers to decline each quarter forever," he said.
When the Qwikster plans were announced, Netflix also said it would add video games to its DVD-by-mail business. But Hastings said the company has given up on that plan as well.
RELATED:
Netflix expects heightened competition from Amazon.com
Netflix growing again, barely beats fourth quarter expectations
Redbox, Warner Bros. headed to war over new DVD rentals
-- Ben Fritz
Photo: Netflix aborted Qwikster.com website. Credit: Netflix
Source: http://latimesblogs.latimes.com/entertainmentnewsbuzz/2012/01/netflix-dvd-video-games.html
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Wednesday, January 25, 2012
Katherine Heigl Has 'Thought A Lot' About Return To 'Grey's Anatomy'
'There's nothing about [Izzie] I didn't like,' Heigl tells MTV News at 'One for the Money' premiere.
By Christina Garibaldi
Katherine Heigl on "Grey's Anatomy"
Photo: ABC
NEW YORK — It's been more than two years since Katherine Heigl left her role as Dr. Izzie Stevens on the hit show "Grey's Anatomy." Rumors swirled that Heigl had behaved like a diva on the set, and after five seasons she left to focus on her movie career and being a mom to her adopted daughter.
Yet it seems she's had a change of heart. At the New York premiere of her new flick "One for the Money," which hits theaters on Friday, Heigl told MTV News she would love to return to "Grey's Anatomy" to find out what happened to her beloved character.
"There was something about her that I really loved. I thought she was such an interesting character and her backstory, the fact that she was raised in a trailer park and had to give a child up for adoption, put herself through med school and was standing there actually doing the work and going for it, so smart, sort of strong-willed," Heigl said. "I thought she was kind of a great character — there's nothing about her I didn't like."
Back in October 2010 Heigl told MTV News that she was certain she would not return to Seattle Grace since she didn't want to feel her plotline was forced. "I can't think of any way that she could come back gracefully that wouldn't just feel manipulative," the actress explained. "And it's hard, because I really wonder what she's doing and where she is and what happened, but that is over for me now."
Yet Heigl now seems ready to reconsider and already has an idea of what could happen to Izzie. "I've thought about this a lot, actually. I would love it if Izzie came back actually having really just sort of gotten to the next level," Heigl said. "She was always sort of one step behind and struggling with her career, and then she went though all these awful things, the death of her friend, the death of her fiancé, her own near death and then the dissolving of her own marriage. I just want the girl to win, just once. So I want her to come back and have really succeeded at whatever hospital she went to work at with her tail between her legs and maybe they've made her head of surgery or she's invented some surgical method; that would be awesome."
With all the ups and downs she experienced on "Grey's Anatomy," there is one thing she wish she could change: her acting. "I think there's a lot of scenes where I wish I had performed them better," Heigl said.
"You're always like, 'Oh, I wish I could take that back.' "
Would you be excited if Katherine Heigl returned to "Grey's Anatomy"? Let us know in the comments!
Source: http://www.mtv.com/news/articles/1677884/katherine-heigl-returning-greys-anatomy.jhtml
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Two more arrested in Europe over Megaupload case (Reuters)
AUCKLAND (Reuters) ? Two men sought worldwide in connection with a U.S.-led crackdown on the online file-sharing website Megaupload have been arrested, a New Zealand government lawyer told a court on Monday.
U.S. authorities had issued international warrants for Sven Echternach, 39, a German, and Andrus Nomm, 32, of Estonia for their involvement in alleged internet piracy and money laundering.
The two had been arrested in Europe, New Zealand government lawyer Anne Toohey told a court hearing on an application for bail by Megaupload's founder Kim Dotcom, also known as Kim Schmitz.
Toohey said Echternach had travelled to Germany from the Philippines, but cannot be extradited because German law does not permit extradition of its own citizens. Nomm had been detained in the Netherlands.
A Slovakian national, Julius Bencko, is still being sought in connection with what U.S. authorities have called the Mega Conspiracy.
Dotcom, 38, and three others, were arrested in New Zealand on Friday after police raided a country estate at the request of the U.S. Federal Bureau of Investigation.
Raids took place in several other countries and the Megaupload site has been shut down, with the business's assets frozen.
On Monday, Dotcom's New Zealand lawyer denied Megaupload was involved in copyright breaches, the pirating of movies and music, and said his client should be given bail, possibly involving electronic tagging.
Toohey said Dotcom was an "extreme flight risk" and should be held in custody ahead of formal hearing on the United States' extradition bid.
U.S. authorities want to extradite Dotcom on charges he masterminded a scheme that made more than $175 million in a few short years by copying and distributing music, movies and other copyrighted content without authorisation. Megaupload's lawyer has said the company simply offered online storage.
(Writing by Gyles Beckford; Editing by Ed Davies and Alex Richardson)
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Tuesday, January 24, 2012
Best Bets: Stephanie Plum hits big screen
Lionsgate Films
Katherine Heigl plays Stephanie Plum in "One For the Money."
By Gael Fashingbauer Cooper
At last, the movies are starting to get ... if not good, at least interesting. And last year's movies are starting to hit DVD and Blu-ray, so if you're snowed in, stock up on films for home viewing.
Movies
Look around the next airport you're in and you'll see dozens of folks?engrossed in?books?from the Stephanie Plum series. Plum is author Janet Evanovich's lingerie-saleswoman-turned-bounty-hunter, and the heroine of her numerically titled books. Now the first in that series, "One For the Money," is coming to the big screen, with the sometimes controversial Katherine Heigl as Plum. Book fans have high hopes, but we'll have to see if Heigl and the cast live up to the characters so many have already imagined in their heads. (Jan. 27.)
Does Liam Neeson really punch a wolf in the snout??In "The Grey," Neeson plays the leader of a group of plane crash survivors who are determined to make it out of the Alaskan wilderness alive. The trailer reveals that even those tiny liquor bottles they put on planes can be a weapon if you really need them to be. (Jan. 27.)
TV
The third "Spartacus" series, "Spartacus: Vengeance,"?comes to TV?this week.?If you watched "Spartacus: Blood and Sand," you know the gladiators have killed their master and escaped his brutal school. But are the Romans going to let them get away without a fight? Don't bet on it. (Jan. 27, 10 p.m., Starz.)
DVD
That poor family in the "Paranormal Activity" series! Apparently they've been cursed for decades, and in "Paranormal Activity 3," hitting DVD this week, we learn about how Katie and Kristi's growing up was more "Addams Family" than "Brady Bunch." The Bloody Mary sequence, where the girls stare into a bathroom mirror and try to summon the supernatural with that old slumber-party game, is jump-out-of-your-seat scary.?(On DVD Jan. 27)
"Real Steel" also hits DVD this week, and it was a bit of a surprise hit at the box office. Sure, it looked like two hours of giant robots pounding each other, "Battlebots" style, but really it was a sweet family film. Hugh Jackman plays the dad and washed-up boxing promoter who gets to know the son he never really cared about as they try to fight their way up the rankings. (On DVD Jan. 27)
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RIM gets a new CEO, and he calls? CrackBerry Kevin
It’s actually happened — after bringing BlackBerry from pager to the top of the smartphone world only to see the iPhone and Android all but demolish their share, RIM today 
 |  |
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/HzHpsKUanV0/story01.htm
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Monday, January 23, 2012
Mysterious 'Winged' Structure from Ancient Rome Discovered (LiveScience.com)
A recently discovered mysterious "winged" structure in England, which in the Roman period may have been used as a temple, presents a puzzle for archaeologists, who say the building has no known parallels.
Built around 1,800 years ago, the structure was discovered in Norfolk, in eastern England, just to the south of the ancient town of Venta Icenorum. The structure has two wings radiating out from a rectangular room that in turn leads to a central room.
"Generally speaking, [during] the Roman Empire people built within a fixed repertoire of architectural forms," said William Bowden, a professor at the University of Nottingham, who reported the find in the most recent edition of the Journal of Roman Archaeology. The investigation was carried out in conjunction with the Norfolk Archaeological and Historical Research Group.
The winged shape of the building appears to be unique in the Roman Empire, with no other example known. "It's very unusual to find a building like this where you have no known parallels for it," Bowden told LiveScience. "What they were trying to achieve by using this design is really very difficult to say."
The building appears to have been part of a complex that includes a villa to the north and at least two other structures to the northeast and northwest. An aerial photograph suggests the existence of an oval or polygonal building with an apse located to the east.?
The winged building
The foundation of the two wings and the rectangular room was made of a thin layer of rammed clay and chalk. "This suggests that the superstructure of much of the building was quite light, probably timber and clay-lump walls with a thatched roof," writes Bowden. This raises the possibility that the building was not intended to be used long term. [Photos of Mysterious Stone Structures]
The central room, on the other hand, was made of stronger stuff, with its foundations crafted from lime mortar mixed with clay and small pieces of flint and brick. That section likely had a tiled roof. "Roman tiles are very large things, they?re very heavy," Bowden said.
Sometime after the demise of this wing-shaped structure, another building, this one decorated, was built over it. Archaeologists found post holes from it with painted wall plaster inside.
Bowden said few artifacts were found at the site and none that could be linked to the winged structure with certainty. A plough had ripped through the site at some point, scattering debris. Also, metal detecting is a major problem in the Norfolk area, with people using metal detectors to locate and confiscate materials, something that may have happened at this site.
Still, even when the team found undisturbed layers, there was little in the way of artifacts. "This could suggest that it [the winged building] wasn't used for a very particularly long time," Bowden said.
The land of the Iceni
Researchers are not certain what the building was used for. While its elevated position made it visible from the town of Venta Icenorum, the foundations of the radiating wings are weak. "It's possible that this was a temporary building constructed for a single event or ceremony, which might account for its insubstantial construction,' writes Bowden in the journal article.
"Alternatively the building may represent a shrine or temple on a hilltop close to a Roman road, visible from the road as well as from the town."
Adding another layer to this mystery is the ancient history of Norfolk, where the structure was found.
The local people in the area, who lived here before the Roman conquest, were known as the Iceni. It may have been their descendents who lived at the site and constructed the winged building.
Iceni architecture was quite simple and, as Bowden explained, not as elaborate as this. On the other hand, their religion was intertwined with nature, something which may help explain the wind-blown location of the site. "Iceni gods, pre-Roman gods, tend to be associated with the natural sites: the springs, trees, sacred groves, this kind of thing," said Bowden.
The history between the Iceni and the Romans is a violent one. In A.D. 43, when the Romans, under Emperor Claudius, invaded Britain, they encountered fierce resistance from them.? After a failed revolt in A.D. 47 they became a client kingdom of the empire, with Prasutagus as their leader. When he died, around A.D. 60, the Romans tried to finish the subjugation, in brutal fashion.
"First, his [Prasutagus'] wife Boudicea was scourged, and his daughters outraged. All the chief men of the Iceni, as if Rome had received the whole country as a gift, were stripped of their ancestral possessions, and the king's relatives were made slaves," wrote Tacitus, a Roman writer in The Annals. ?(From the book, "Complete Works of Tacitus," 1942, edited for the Perseus Digital Library.)
This led Boudicea (more commonly spelled Boudicca) to form an army and lead a revolt against the Romans. At first she was successful, defeating Roman military units and even sacking Londinium. In the end the Romans rallied and defeated her at the Battle of Watling Street. With the Roman victory the rebellion came to an end, and a town named Venta Icenorumwas eventually set up on their land.? [Top 12 Warrior Moms in History]
"The Iceni vanish from history effectively after the Boudicca revolt in [A.D.] 60-61," said Bowden.
But while they vanished from written history, archaeological clues hint that their spirit remained very much alive. Bowden and David Mattingly, an archaeologist at the University of Leicester, both point out that the area has a low number of villas compared with elsewhere in Britain, suggesting the people continued to resist Roman culture long after Boudicca's failed revolt.
This lack of villas, along with problems attracting people to Roman settlements in the area, "can be read as a transcript of resistant adaption and rejection of Roman norms," writes Mattingly in his book "An Imperial Possession: Britain in the Roman Empire" (Penguin Books, 2007).?
There is "still a fairly strong local identity," said Bowden, who cautioned that while local people may have lived at the complex, the winged building is out of character for both Roman and Iceni architectural styles, a fact that leaves his team with a mystery.
Follow LiveScience for the latest in science news and discoveries on Twitter @livescience?and on Facebook.
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Asthma Meds Likely Safe During Pregnancy: Study (HealthDay)
FRIDAY, Jan. 20 (HealthDay News) -- A new study found no statistically significant link between asthma medication use during pregnancy and common birth defects.
However, the study did find a positive association between some rare birth defects and mothers with asthma, and potentially with their medication use. But, the researchers couldn't tease out whether the problem was a loss of oxygen from less than well-controlled asthma or an effect of medications.
"Worsening asthma is a risk to the mom and the fetus. Hypoxia (a lack of oxygen) we know is a problem for a developing fetus. And, the potential risk they found here is very small. Even if it turns out to be a true increase, the risk is so small. This study raises more questions than it answers," said Dr. Natalie Meirowitz, chief of the division of maternal fetal medicine at Long Island Jewish Medical Center in New Hyde Park, N.Y.
What's most important, she said, is that expectant mothers with asthma don't just stop their medications. "That's really a problem, and then they end up needing more medication," she said.
Findings from the study were published online Jan. 16, ahead of February print publication in Pediatrics.
Between 4 percent and 12 percent of expectant mothers have asthma, according to background information in the article. Current guidelines recommend that women keep taking their asthma medications during pregnancy.
There are two main types of asthma medications: bronchodilators (also known as rescue medication) and anti-inflammatories, which include inhaled and oral steroids, as well as several other medications. Anti-inflammatory medications are generally used long term to help control asthma symptoms.
For the study, the researchers compared nearly 2,900 infants born with birth defects to more than 6,700 babies born with no birth defects. Mothers of these infants were asked to recall their medication use one month before and during pregnancy.
For most birth defects, the researchers found no statistically significant associations between asthma medication use and the development of birth defects.
They did, however, find a positive association between asthma medication use and certain rare birth defects. The risk of isolated esophageal atresia -- an abnormality of the esophagus -- was more than doubled in women who used bronchodilators. The risk of isolated anorectal atresia -- a malformed anus -- was more than doubled with maternal anti-inflammatory use. And, the risk of omphalocele -- a defect in the abdominal wall -- was more than quadrupled for either type of asthma medication.
But, the authors wrote, the "observed associations may be chance findings or may be the result of maternal asthma severity and related hypoxia rather than the medication use."
They added that it's also important to keep these findings in context. The rate of these birth defects ranged from 1.2 to 4.6 per 10,000 births. So, even a four-fold increase in the risk of having one of these defects results in far less than a 1 percent chance for any individual woman and her child.
"As obstetricians, we need to pay attention to this, but it's really important to oxygenate mom. We really need to make sure that there's oxygen flowing freely between mom and baby," said Dr. Mary Rosser, an obstetrician with Montefiore Medical Center in New York City.
Also, Rosser pointed out that there was a lot that wasn't known about the expectant mothers. The authors weren't able to assess the severity of their asthma. They also didn't know anything about the medication doses.
Asthma expert Dr. Jennifer Appleyard agreed with Rosser and Meirowitz. "They really couldn't tease apart what was the medicine and what was the asthma," she said.
"You need to treat the asthma. There's more risk to uncontrolled asthma than a slight possible risk of a rare birth defect," said Appleyard, the chief of allergy and immunology at St. John Hospital and Medical Center in Detroit.
"No matter what type of patient you're treating -- expectant mom or not -- the goal is to treat patients with the minimum amount of medication necessary," she added.
Rosser and Meirowitz said that, ideally, women should visit their obstetrician/gynecologist before getting pregnant to review their medication use and to make sure that their asthma is well controlled.
More information
Learn more about asthma during pregnancy from the American College of Allergy, Asthma and Immunology.
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Sunday, January 22, 2012
Zelboraf: Treat One Cancer, Speed Up Another?. In the Pipeline:
? Dapagliflozin Goes Down (For the Last Time?) | Main | Alnylam Cuts Back Hard ?
January 20, 2012
Zelboraf: Treat One Cancer, Speed Up Another?
You may well recall the excitement around the late-stage clinical data for Zelboraf (vermurafenib, PLX4032) in metastatic melanoma. The drug was approved late last summer, but (like all the other therapeutic options in oncology), it has its issues.
One of those appears to be speeding up the course of squamous cell carcinoma. (Here's the NEJM article and the accompanying editorial). A significant number of patients on Zelboraf have turned up with this other form of skin cancer. To be sure, they surely had these cancerous cells beforehand (which tend to feature RAS mutations), but the effects of the drug on the MAP-kinase pathway seem to kick up their activity. (The same effect is seen on melanoma cells that don't have the V600E mutation - if you give Zelboraf without genotyping the patient first, you risk making things much worse). One obvious fix would be to give a combination, something to target those squamous cells, and thus the idea of co-administering an MEK inhibitor. Squamous cell carcinomas can be removed, and are nowhere near as bad as melanoma (particularly metastatic melanoma), but this is still a problem.
A bigger problem is that (as mentioned in my older post on this drug) resistant melanoma crops up pretty quickly after initial treatment with Zelboraf. Virtually all of the people taking the drug will eventually die of metastatic melanoma; it's just going to take longer. But how much longer, we don't know. The numbers still aren't quite in on overall survival - it's going to be more than the previous standard of care, but it's probably not going to be overwhelmingly more. Of course, the definition of "more" and the value that an individual patient places on it (or an insurance company places on it), well, those are the very things that keep us arguing about health care. Maybe that MEK co-therapy will make it an easier call?
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Source: http://pipeline.corante.com/archives/2012/01/20/zelboraf_treat_one_cancer_speed_up_another.php
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Nadal, Federer win; Isner last US man to leave
Switzerland's Roger Federer celebrates after winning the first set against Croatia's Ivo Karlovic during their third round match at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/Andrew Brownbill)
Switzerland's Roger Federer celebrates after winning the first set against Croatia's Ivo Karlovic during their third round match at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/Andrew Brownbill)
Rafael Nadal of Spain serves to Lukas Lacko of Slovakia during their third round match at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/Andrew Brownbill)
John Isner of the US reacts to a lost point during his third round match against Spain's Feliciano Lopez at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/Rick Rycroft)
Spain's Rafael Nadal passes his towel to a ball boy during his third round match against Slovakia's Lukas Lacko at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/John Donegan)
A bird flies across Rod Laver Arena with food in it's mouth as Slovakia's Lukas Lacko looks on during his third round match against Spain's Rafael Nadal at the Australian Open tennis championship, in Melbourne, Australia, Friday, Jan. 20, 2012. (AP Photo/John Donegan)
MELBOURNE, Australia (AP) ? Rafael Nadal and Roger Federer are taking similar paths to a potential semifinal matchup at the Australian Open.
A rematch of the women's 2011 final is already in place, with defending champion Kim Clijsters and China's Li Na winning Friday to set up a meeting in the fourth round.
Meanwhile, the last U.S. man fell out of the tournament when No. 16 John Isner lost to Spaniard Feliciano Lopez 6-3, 6-7 (3), 6-4, 6-7 (0), 6-1. It marks the first time since the start of the Open Era in 1968 that no American men have reached the fourth round at the Australian Open
Neither the four-time Australian champion Federer nor 2009 titleholder Nadal have dropped a set, although Federer's path was made easier by a walkover win in the second round. They are in the same half of a Grand Slam singles draw for the first time since 2005.
The longtime rivals played back-to-back matches at Rod Laver Arena on Friday. Nadal, his right knee still taped from a recent injury, showed no problems while moving briskly around the court in a 6-2, 6-4, 6-2 win over qualifier Lukas Lacko.
Federer then edged Ivo Karlovic 7-6 (6), 7-5, 6-3, saving a set point in the tiebreaker with a scrambling lob over the 6-foot-10 Croatian. Nadal will face Lopez, and Federer will play Australian teenager Bernard Tomic on Sunday.
"He gave me a second serve and gave me a slight chance," Federer said. "Might have had a little bit of a lucky volley."
Karlovic agreed.
"It was unlucky ... one in a 100 that I'm going to lose that point," Karlovic said. "I didn't really expect him to do that. I was there, I just miscalculated how much I was jumping. If I would have won that, everything would be different, but that's life."
Nadal had few dramas in his match against Lacko. Over the weekend, he felt a sharp pain in his knee while sitting in his chair in his hotel. He initially feared it would cause him to withdraw from the tournament.
Three matches later, Nadal says "the knee is fine ... being in the fourth round without losing a set, it's fantastic news."
Isner was disappointed with the outcome of his match. The last American to win the Australian Open was Andre Agassi in 2003, his third win in four years at Melbourne Park.
"It's very ugly, to be honest, to have no one in the round of 16 ... very disappointing, not a good effort from the Americans," Isner said. "We've got to try to rectify that next time the big tournaments roll around."
No. 7 Tomas Berdych beat No. 30 Kevin Anderson of South Africa 7-6 (5), 7-6 (1), 6-1 and will play No. 10 Nicolas Almagro of Spain, who beat 21st-seeded Stanislas Wawrinka of Switzerland 7-6 (2), 6-2, 6-4.
Philipp Kohlschreiber of Germany defeated Alejandro Falla of Colombia 6-3, 6-2, 7-6 (3), 11th-seeded Juan Martin del Potro beat Yen-Hsun Lu of Taiwan 6-2, 6-3, 6-0 and Tomic defeated 13th-seeded Alexandr Dolgopolov of Ukraine 4-6, 7-6 (0), 7-6 (6), 2-6, 6-3. Del Potro plays Kohlschreiber in the fourth round.
Defending champion Novak Djokovic and fourth-seeded Andy Murray, who has lost in the final at Melbourne Park the last two years, play their third-round matches Saturday, with a Djokovic-Murray replay possible in the semifinal.
On the women's side, top-seeded Caroline Wozniacki has not dropped a set in her quest for a first Grand Slam title. She beat Monica Niculescu of Romania 6-2, 6-2 Friday, and third-seeded Victoria Azarenka defeated Mona Barthel 6-2, 6-4.
On their side of the draw, Wozniacki could face Clijsters in the quarterfinals. But before Clijsters gets that far, she will have to beat French Open winner Li.
Li advanced when Anabel Medina Garrigues had to retire with an ankle injury midway through the first set.
"It was really tough, because she tried to continue to play, so I don't know (if) it's like real or fake ... some players they do that," Li said. Then, "I saw she couldn't run and she started to cry. I have to say I am so sorry for her."
Clijsters eased past Daniela Hantuchova 6-3, 6-2 at Hisense Arena. Clijsters' only loss to Hantuchova in 11 matches came at Brisbane two weeks ago when she withdrew with a hip injury in the second set of their semifinal.
On Saturday, the two biggest threats in the other half of the draw, five-time champion Serena Williams and 2011 Wimbledon winner Petra Kvitova, play for a spot in the last 16.
Williams will face Greta Arn of Hungary, while Kvitova will play Maria Kirilenko of Russia.
Wozniacki, who needs to reach the quarterfinals to have any chance of retaining the No. 1 ranking, will face Jelena Jankovic. She beat American Christina McHale 6-2, 6-0.
Azarenka, who defeated Li to win the Sydney International last week, has only lost eight games at Melbourne Park. She remains one of three women who can overtake Wozniacki for the top ranking at the Australian Open.
The 22-year-old player from Belarus will meet Czech player Iveta Benesova, who beat Russian qualifier Nina Bratchikova 6-1, 6-3.
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Saturday, January 21, 2012
Huawei Honor review
Continue reading Huawei Honor review
Huawei Honor review originally appeared on Engadget on Sat, 21 Jan 2012 09:35:00 EDT. Please see our terms for use of feeds.
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